珍妮特Duerr

最近的新闻

教育

1987 Ph.D., 生物学, >ence specialization, Department of 生物学, Princeton University, Princeton, NJ. 论文指导老师:博士. 威廉·奎因. 论文: A genetic and cellular analysis of behavioral plasticity in 果蝇 melanogaster.

1981 M.S., 生物学, Department of 生物学, Princeton University, Princeton, NJ

1978 B.S., 生物学, Department of 生物学, Stanford University, Stanford, CA

杜尔实验室网站

课程

• BIOS 1700: Biological Sciences I: Molecules and Cells
• BIOS 3105: Laboratory Genetics (team-taught)
• BIOS 3200: Fundamentals of Animal Cell 生物学
• BIOS 3205: Cell & 微生物学技术
• MCB7600: Advanced Cell 生物学 (team-taught)

研究兴趣

• 实验室:生命科学楼240号

The research in our laboratory uses a model organism, the small soil nematode 秀丽隐杆线虫, to examine the development and function of the nervous system. C. 线虫 is a wonderful animal for studying the nervous system, since many of the genes and processes necessary for nervous system development and function are conserved in humans. 然而, C. 线虫 has only 302 neurons controlling its simple behaviors, rather than the hundreds of billions of neurons needed to generate complex behaviors in humans. We use genetics (including transgenic animals), 分子生物学, 细胞生物学, 显微镜, and behavioral assays to examine the development, 分布, and function of genes that are necessary for neuronal signaling using monoamine neurotransmitters.

在人类, monoamines are important for modulating behaviors such as arousal and reward; proteins that alter the uptake and 释放 of monoamines are targets of several psychoactive drugs. Monoamines are also important for the modulation of specific simple behaviors in C. 线虫. We are studying the development and function of several genes that are required for the normal function of monoaminergic neurons, 包括合成酶, vesicular and plasma membrane transporters, and putative monoamine degradation enzymes. We are interested in understanding how acute and chronic changes in these proteins alter monoamine-dependent behaviors and sensitivity to monoamines. What short-term or developmental changes occur when monoamine synthesis, 释放, 再吸收, and/or degradation are perturbed? We expect that understanding changes in this simple animal will increase our understanding of the much more complex changes that occur when monoamines are altered in humans.

传记

I have always been interested in understanding how the nervous system controls behavior. My first laboratory experiences, while earning my B.S. 在生物学中 at Stanford University, were using ground squirrels to understand thermoregulation. 我获得了博士学位.D. 在生物学中, with a concentration in >ence, at Princeton University in 1987, studying the genetic bases of learning and memory in 果蝇. During a post-doc at the 加州大学, 加州大学伯克利分校, I used cellular imaging techniques to study early neuronal development in the grasshopper. I then began work on my current project, using the nematode C. 线虫 to study how the nervous system directs behavior. We study many levels of organization, from individual genes through cells and circuits and behavioral outputs, both during development and in the adult. This research was started as a post-doc, then continued during my work as a 研究 Scientist at the Oklahoma Medical 研究 Foundation. I moved to newbb电子平台 in 2002, to combine my research activities with teaching and mentoring.

就业

2008-present 副教授, Department of Biological Sciences, newbb电子平台. 研究 examines neurotransmitter trafficking and epigenetics using a model organism, the nematode C. 线虫.

2002-08 Assistant Professor, Department of Biological Sciences, newbb电子平台.

2001-02 Assistant 研究 Member, Oklahoma Medical 研究 Foundation (OMRF).

1992-2000 Senior 研究 Scientist with Dr. 詹姆斯·兰德，OMRF.

1991-92 Associate 研究 Scientist with Dr. 詹姆斯·兰德，OMRF.

1987-90 Postdoctoral research fellow with Professor David Bentley, Department of Molecular and Cell 生物学, 加州大学, 加州大学伯克利分校, CA. 研究 examined navigation by pioneer neurons in the grasshopper limb.

代表的出版物

Duerr J.S. , H.P. 汉族,年代.D. 字段,J.B. 兰特(2008) Identification of major classes of cholinergic neurons in the nematode 秀丽隐杆线虫. J比较神经病学 506:398-408.

马修斯E.A., G.P. 马伦J.A. Crowell J.S. 杜尔，J.R. 麦克马纳斯,. 杜克,J. 束帆索,J.B. 兰特(2007) Differential expression and function of synaptotagmin 1 isoforms in 秀丽隐杆线虫. Mol细胞神经科学. 34(4):642-52.

Duerr J.S. (2006)免疫组织化学. 在WormBook, ed. C. 线虫研究协会., 61p. doi / 10.1895 / wormbook.1.105.1.

Duerr J.S. , J. 加斯金和J.B. 兰特(2001) C中已识别的神经元. 线虫 coexpress vesicular transporters for acetylcholine and monoamines, Am. J. Physiol细胞物理. 280:C1616-C1622.

Duerr J.S. , D.L. 弗里斯比J. 束帆索,. 杜克,K. Asermely D. 哈迪,我.E. 艾登和J.B. 兰特(1999) The cat-1 gene of 秀丽隐杆线虫 encodes a vesicular monoamine transporter required for specific monoamine-dependent behaviors, J. >. 1:72-84.