王少华博士.D.
教育
- 肠道微生物组 and human health, University of South Florida (研究 Associate), 2022
- 肠道微生物组 and bacterial infections/ageing, Wake Forest University (研究 Fellow), 2021
- Genomic engineering with Clostridia, Auburn University (Postdoc), 2017
- Microbiology (Probiotics and bacteriophages), Shandong University (PhD), 2010
专业知识
- 细菌感染
- Clostridioides difficile
- 益生菌和益生元
- Genomic engineering (CRISPR/Cas9)
- 肠道微生物组
- Short chain fatty acids
- 抗衰老
- 噬菌体
- Antibiotics alternatives
工作总结
We focus largely on the bacterial pathogen studies especially Clostridioides difficile (C. 困难的). C. difficile is the most common hospital acquired infections, with high rate of antibiotic resistance and recurrence incidences, became a debilitating public health threat, with no successful preventive and treatment options.
We are interested in exploring the pathogenic mechanisms (related genes, 蛋白质, pathways) and biomarkers by genetic engineering; and conducting projects that elucidate the effects of probiotics/prebiotics/natural metabolites on gut microbiome modulation to attenuate C. difficile infection (CDI) and recurrent CDI (rCDI). We would also discover new drugs (as antibiotics alternatives) and develop new systems to prevent and treat CDI/rCDI. 此外, we will also be interested to extend therapeutic strategies to other emergency pathogens to improve human health.
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